DR SIMON POWIS

describe the process of a naive T cell becoming activated and causing many more T cells to be produced this is a classic exam question so I have put it at the top of the page cause its important

Naive T-cells express a low-affinity IL-2 Receptor on its cell surface membrane

once the T-cell becomes activated a new chain is added and the receptor is now classed as a high affinity IL-2 receptor. The T-cell now secretes IL-2 which then binds to the receptor, this then sends a signal to the T-cell and the signal induces T-cell poliferation

• To understand how B and T cells are activated and the cytokines they secrete.

B cells are activated by either dendritic cells when they bring antigen to the local lymph nodes or by T cells such as CDK4 Th2 activating B cells for antibody response

T cell can secrete IL-2 as part of an autocrine response the IL-2 binds to a receptor on the T cell’s surface itself which results in further T cell proliferation

• To list and describe the function of T cell subsets.

CDK 8 is a type of T cell it is known as a cytotoxic T cell which is used to combat infected cells

CDK4 has two subtypes

Th1 + Th2

Th1 = secretes IFN-gamma + TNF-alpha and it activates macrophages, B cells and optimised antibodies such as IgG1

Th2 = secretes IL-4 and activated B cells for an antibody response

• function of dendritic cells