occurs from birth causing infants to be unable to produce sufficient thyroid hormones
early diagnosis and immediate treatment is required otherwise permanent neurological deficits occur.
there are 2 main causes of congenital hypothyroidism
Primary (in thyroid itself) and central (made up of secondary pituitary and tertiary hypothalamic)
the most common by far is primary thyroid development which makes up for 80% of cases of congenital hypothyroidism
Primary transient causes inc
mother taking -
glucocorticoids, amiodarone, somatostatin
MATERNAL ANTI-THYROID DRUGS
iodine deficiency or opdone excess causing wolf chaikof effect
(WCE = reduction in thyroid hormones caused by ingestion of large amounts of iodine)
Clinical features of congenital hypothyroidism