Dr Alan Hughes

• To define the four main criteria of ADME (i.e. what does each letter stand for, and in brief what does each process represent?)

E- excretion (think em doll but scottish)

M- metabolism

D- Distribution

A - absorpition

L - liberation

• To list the major routes of drug administration plus their benefits and drawbacks.

that big table in ankis (i smashed it on the 17th o’ march so u best keep at it only took half a day)

• To relate the general chemical properties of a drug to its subsequent absorption and distribution throughout the body (i.e. identify the major factors that influence abosorption and distribution - for example, ionisation)
• ionisation (charged molecules cannot get across membranes, rem molecules must be uncharged to get across then they become charged on the inner side)
• pH compartments
• Cardiac output
• polar body protein binding ( Albumin, a-1 glycoprotein, lipoprotein, globulins)
• Capillary permuability
• degree of lipophilic

there are 4 ways that drugs may enter cells

pinocytosis & through small channels such as aquaporons are rare because molecules are generally not small enough to be able to fit through aquaporons and molecules that are big enough to be pinocytosed are usually inserted as a drug IV where absorption would not be a problem, they are inserted this way because otherwise they would be degraded quickly by the stomach because of their size