Dr Janet Cox-Singh

• Define Sepsis and explain the differences between Sepsis, Septic Shock and Systemic Inflammatory Response Syndrome (SIRS).

sepsis - SEPSIS is the result of infection that leads to tissue dysfunction distal to site of infection it basically causes out of control inflammation dysfunction

septic shock - Severe sepsis develops when the infection causes organ damage. Septic shock is the most severe form in which the infection causes low blood pressure, resulting in damage to multiple organs.

systemic inflammatory response syndrome (SIRS) - I think it is the response that happens because of sepsis ie it is the inflammatory response

• List the infections that can lead to Sepsis.

gram negative and gram positive infections can lead to sepsis

gram pos - Streptococci pneumoniae and Staphylococcus aureus

gram neg - E. coli, Klebsiella pneumonia

• Describe the characteristics and function of normal Innate Immunity.

normal innate immunity includes

PAIN - the sensation of pain is sent to your body to tell you that something is wrong

HEAT - a fever occurs as pathogens usually thrive at 37c so if internal body temperature is risen pathogens will struggle to survive