explain how a drop in blood volume causes aldosterone synthesis

kidney detects drop in Bvolume and releases renin.

renin then cleaves angiotensinogen to angiotensin I

angiotensin I becomes Ang II (via the Angiotensin converting enzyme ACE which is secreted by the epithelia of the lung)

angiotensin II targets the zoma glomerulosa cells in the adrenal cortex which activates an aldosterone synthase enzyme within the cells to synthesise aldosterone.

aldosterone is released and targets distil regions in the kidney to reabsorb sodium and H2o to then inc BV and BP

ALDOSTERONE MOA

What is the role of

11B-HYDROXYSTEROID DEHYDROGENASE (11B-HSD)

this converts active cortisol into an inactive form known as cortizone

when this is active it means that cortisol cannot interfere ith the effects of aldosterone