List the main fungal agents that infect humans and the disease entities that they cause
List the main groups of anti-fungal drugs
Block P450 and sterol 14 alpha demethylase in the cell wall
inhibits fungal cytochrome P450 enzyme 14α-demethylase Prevents conversion of lanosterol → ergosterol Primarily fungistaticMay have dose-dependent fungicidal activity for some organisms
Inhibits squalene epoxidase which is a key part of the fungal wall - the inhibition of this creates a compound which when broken down is toxic and causes cell death to the fungi
Inhibit and form pores in fungal membrane
Amphotericin B binds with ergosterol in fungal cell membranes Pores form which cause rapid leakage of monovalent ions (K+, Na+, H+ and Cl−) and fungal cell death.
