endothelial cells become damaged, platelets attach onto the site, then release granules (Pf4, TXA2,ADP) which attract other platelets to the site, Platelets have GPIb which allow them to bind onto von willebrand’s factor. GPIIB-IIIa allows for platelets to bind to lines of fibrinogen which attach them to each other (fibrinogen acts like glue). passing molecules e.g. neutrophil’s & RBC may get caught up in the complex.

after this build up the blood. vessel releases t-PA (fibrinolysis) and thromboomodulin to try to breakdown the complex

thrombosis is a clot formed in the cardiovascular system during life, it is denoted on histology slides by white streaks coupled with Red sheets, the red sheets signifying RBC’s and the white sheets signifying thrombosis as fibrin + platelets