describe the pathology of type II glomerularopathy

you have antibodies which are directed at the glomerular basement membrane

(IgG) IT THEN ACTIVATES compliment which causes a hole to be punched in the basement membrane which means that everything can get through including RBCs.

the proteins that are entering are also activated due to compliment. and so they are forming fibrin and producing compounds which cause inflammatory cells to come towards them which causes acute inflammation

(overall the effected glomeruluses are undergoing acute inflammation and are leaking proteins  due to the hole punched in the basement membrane by complement)

this results in no urine being able to be produced due to massive inflammations of glomeruluses

also good to note that the epithelial cells which surround the bowman's capsule when exposed to fibrin they undergo proliferation which crush the glomeulus blood supply as they can only proliferate inwards. which means blood cannot go in or out of the glomerulus = no nephron blood supply (as this is where the blood goes to supply after the glomerulus) which means death of nephron.

in Type II glomerularopathy BOTH kidneys and every nephron is effected

describe the pathology of Type III glomerularnephritis

immune complexes fix complement which help them to punch holes into the glomerulus and they get trapped between layers causing inflammation and degrading the glomeruluses basemement membrane's electrical charge.

this reaction is on a spectrum between acute and chronic and it depends how big/small the autoimmune complexes are and how severe the infection may be.

there will be proteinuria due to the various holes in the glomerulus