everything present in the table below is a non-depolarising blocker with the exception of suxamethonium which is a depolarising drug which stimulates action potentials
| Drug | Onset | Duration | Main side-effects |
|---|---|---|---|
| Pancuronium | Medium | Long | Tachycardia |
| Vecuronium | Medium | Medium | Few side-effects |
| Rocuronium | Fast | Medium | Tachycardia |
| Atracurium | Medium | Medium | Hypotension / bronchospasm |
(histamine release) | | Mivacurium | Fast | Short | Hypotension / bronchospasm (histamine release) | | Suxamethonium | Fast | Short | Bradycardia (muscarinic agonist effect) Cardiac dysrhythmias (increased plasma K+ concentration) Raised intraocular pressure (nicotinic agonist effect) Postoperative myalgia (muscle fasciculations) Malignant hyperthermia (ryanodine receptor related) |
if you have liver problems what happens with metabolism/elimanation of drug effects? patients do not have control of their muscle for a longer period of time
local anasthetics in high enough doses will not only stop pain but it will also inhibit muscle contraction
botulinum toxin - botox why is it used?
hyperhydrosis - excessive sweating
and cosmetic
two molecules of ACh are required to bind to a nicotinic receptor to open the channel and allow depolarisation of the muscle cell to occur
3 ways of blocking neuromuscular transmission